Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879945 | 0.86 | KMT2A (0.41) | FLT3KMT2AMEN1RXFP1NPC1 | |
| SCHEMBL7879710 | 0.86 | DRD2 (0.31) | HRH4DRD2DRD3HRH3 | |
| SCHEMBL7884567 | 0.86 | KMT2A (0.43) | FLT3KMT2AMEN1RXFP1NPC1 | |
| SCHEMBL7880873 | 0.85 | RXFP1 (0.43) | FLT3KMT2AMEN1RXFP1NPC1 | |
| SCHEMBL7879877 | 0.84 | FLT3 (0.42) | FLT3KMT2AMEN1RXFP1NPC1 | |
| SCHEMBL7879493 | 0.84 | SCN9A (0.33) | ARHRH3 | |
| SCHEMBL7880987 | 0.83 | KMT2A (0.41) | FLT3KMT2AMEN1RXFP1NPC1 | |
| SCHEMBL7881140 | 0.82 | RXFP1 (0.45) | FLT3KMT2AMEN1RXFP1ROCK2 | |
| SCHEMBL7882240 | 0.82 | HRH4 (0.36) | HRH4DRD2DRD3HRH3 | |
| SCHEMBL7873680 | 0.82 | KMT2A (0.42) | FLT3KMT2AMEN1RXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |