Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951011 | 0.91 | LMNA (0.39) | CYP2C9HTTLMNAKCNQ3KCNQ2 | |
| SCHEMBL7952535 | 0.89 | TNKS (0.43) | CYP2C9HTTLMNAKCNQ3KCNQ2 | |
| SCHEMBL5755561 | 0.84 | MAPT (0.47) | GRIN1GRIN2BTYMPCYP2C9KDM4E | |
| SCHEMBL8385492 | 0.82 | TNKS (0.46) | TYMPRAB9AHIF1AAKR1C3AKR1C2 | |
| SCHEMBL5755396 | 0.78 | CYP1A2 (0.50) | GRIN1GRIN2BCYP2C9KDM4ECYP1A2 | |
| SCHEMBL13440269 | 0.76 | CA12 (0.44) | KDM4ESMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL7953052 | 0.74 | P2RX1 (0.39) | GRIN1GRIN2BCYP2C9KDM4ECYP1A2 | |
| SCHEMBL7957104 | 0.74 | ATM (0.46) | CYP2C9CYP1A2CYP3A4CYP2C19KCNQ3 | |
| SCHEMBL7044889 | 0.73 | LMNA (0.41) | HTTLMNANPSR1KMT2AALDH1A1 | |
| SCHEMBL7041119 | 0.73 | LMNA (0.43) | HTTLMNANPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11260402-A | — | — | None | — | — | JP | disclosed |
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |
| JP-H11260402-A | NONAQUEOUS ELECTROLYE BATTERY | ASAHI DENKA KOGYO KK | 1999-09-24 | — | — | JP | disclosed |
| US-5869509-A | TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-02-09 | — | — | US | disclosed |