Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519052 | 0.97 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL23828672 | 0.97 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL13962337 | 0.97 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL433324 | 0.97 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL3439938 | 0.93 | HRH3 (0.75) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL17525461 | 0.90 | HRH3 (0.71) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL5665906 | 0.90 | HRH3 (0.93) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL13334881 | 0.88 | HRH3 (0.68) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL3156252 | 0.87 | HRH3 (1.00) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL9371058 | 0.87 | HRH3 (1.00) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262046-B1 | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists | PFIZER INC. | 2001-07-17 | — | — | US | disclosed |
| US-6262046-B1 | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists | PFIZER INC. | 2001-07-17 | — | — | US | disclosed |
| EP-1023285-A1 | AZETIDINYLPROPYLPIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS TACHYKININ ANTAGONISTS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999001451-A1 | AZETIDINYLPROPYLPIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1999-01-14 | — | — | WO | disclosed |