Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.57 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.57 |
| ▸ | RAD52 | P43351 | 3/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7945697 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL99575 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL7943597 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL2885543 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL98010 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL23628576 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL2890099 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL7941283 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL3020141 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 | |
| Hydrochloric Acid SCHEMBL4615116 | 1.00 | HSP90AA1 (0.57) | HSP90AA1PLA2G1BATG4BRAD52PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251379-B1 | KERATOSE WITH QUATERNARY AMMONIUM SALT AND SILICONE DERIVATIVES | SHISEIDO CO., LTD. (JP) | 2001-06-26 | — | — | US | disclosed |