Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944448 | 1.00 | MEN1 (0.47) | MEN1KMT2AHTR5ABDKRB1OPRL1 | |
| SCHEMBL8005369 | 0.86 | BDKRB1 (0.44) | MEN1KMT2AHTR5ABDKRB1HDAC4 | |
| SCHEMBL7952672 | 0.83 | MEN1 (0.65) | MEN1KMT2AHTR5AOPRL1OPRM1 | |
| SCHEMBL7226427 | 0.83 | MEN1 (0.65) | MEN1KMT2AHTR5AOPRL1OPRM1 | |
| SCHEMBL7951355 | 0.83 | MEN1 (0.65) | MEN1KMT2AHTR5AOPRL1OPRM1 | |
| SCHEMBL8014907 | 0.83 | BDKRB1 (0.46) | MEN1KMT2AHTR5ABDKRB1KDM4E | |
| SCHEMBL8020556 | 0.82 | ALDH1A1 (0.49) | MEN1KMT2AHTR5ABDKRB1KDM4E | |
| SCHEMBL14342741 | 0.81 | BDKRB1 (0.41) | MEN1KMT2AHTR5ABDKRB1NPC1 | |
| SCHEMBL5485122 | 0.81 | BDKRB1 (0.41) | MEN1KMT2AHTR5ABDKRB1NPC1 | |
| SCHEMBL5485126 | 0.81 | BDKRB1 (0.41) | MEN1KMT2AHTR5ABDKRB1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228861-B1 | BENIGN PROSTATIC HYPERPLASIA; ANTICHOLESTEROL AGENTS; IMPOTENCY; INTRAOCULAR PRESSURE; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-05-08 | — | — | US | disclosed |
| US-6172066-B1 | HYPOTENSIVE AGENTS; ANTICHOLESTEROL AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-01-09 | — | — | US | disclosed |