Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.58 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.51 |
| ▸ | MMP9 | P14780 | 2/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936664 | 0.88 | ADAM17 (0.58) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10263212 | 0.85 | ADAM17 (0.80) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL7941338 | 0.85 | ADAM17 (0.55) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL7941643 | 0.84 | ADAM17 (0.54) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL7934918 | 0.77 | ADAM17 (0.82) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10263152 | 0.76 | ADAM17 (0.81) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10200964 | 0.74 | ADAM17 (0.77) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10263636 | 0.74 | ADAM17 (0.78) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL7935219 | 0.74 | ADAM17 (1.00) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13924235 | 0.74 | ADAM17 (0.54) | ADAM17TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054278-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |