Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 2/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7941789 | 0.84 | CHRM2 (0.33) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| SCHEMBL7935564 | 0.84 | CHRM2 (0.33) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| SCHEMBL7944558 | 0.83 | CHRM2 (0.45) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| SCHEMBL7943116 | 0.82 | CHRM2 (0.33) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| SCHEMBL7935479 | 0.81 | BACE1 (0.34) | CTSDBACE1BACE2CHRM2CHRM4 | |
| SCHEMBL12301424 | 0.81 | CHRM2 (0.32) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| SCHEMBL12248314 | 0.79 | APLNR (0.31) | CTSDBACE1BACE2 | |
| SCHEMBL15483093 | 0.77 | BACE1 (0.35) | BACE1BACE2RXRAGRIN1GRIN2B | |
| SCHEMBL18478409 | 0.76 | POLB (0.50) | — | |
| SCHEMBL12301746 | 0.76 | POLB (0.40) | CTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |