Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.67 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.65 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.65 |
| ▸ | HRH2 | P25021 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 8/20 | 0.64 |
| ▸ | RAD52 | P43351 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8014300 | 0.93 | HRH3 (0.69) | HRH3PABPC1EIF4HHRH2HRH1 | |
| SCHEMBL7935378 | 0.86 | ACHE (0.60) | ACHEBCHE | |
| SCHEMBL8018033 | 0.84 | BCHE (0.58) | ACHEBCHE | |
| SCHEMBL7944432 | 0.83 | BCHE (0.65) | ACHEBCHE | |
| SCHEMBL7944443 | 0.81 | BCHE (0.57) | HRH3ACHEBCHE | |
| SCHEMBL7935359 | 0.80 | BCHE (0.61) | ACHEBCHE | |
| SCHEMBL7941639 | 0.79 | ACHE (0.61) | ACHEBCHE | |
| SCHEMBL7946303 | 0.79 | BCHE (0.55) | ACHEBCHE | |
| SCHEMBL8020560 | 0.79 | BCHE (0.60) | ACHEBCHE | |
| SCHEMBL7944955 | 0.78 | BCHE (0.61) | HRH3ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | claimed |
| US-6248750-B1 | CHOLINERGIC FUNCTION AGONISTS FOR MEMORY ENHANCEMENT | HOECHST ROUSSEL PHARMACEUTICALS | 2001-06-19 | — | — | US | disclosed |
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0288852-B1 | 9-HYDROXYAMINO TETRAHYDRO-ACRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-28 | — | — | EP | disclosed |