Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.49 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10263969 | 0.89 | ADAM17 (0.48) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10263144 | 0.87 | ADAM17 (0.67) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10262983 | 0.82 | ADAM17 (0.66) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL7946028 | 0.80 | ADAM17 (0.42) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10263220 | 0.80 | ADAM17 (0.65) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10263443 | 0.79 | ADAM17 (0.70) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL7941713 | 0.78 | ADAM17 (0.51) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10268209 | 0.78 | ADAM17 (0.57) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL10263970 | 0.76 | ADAM17 (0.56) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL7944150 | 0.76 | ADAM17 (0.81) | ADAM17ADAM10MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054278-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |