Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 5/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622696 | 0.94 | SCN9A (0.44) | PRKCIPRKCZKDM4EHSD17B10TP53 | |
| SCHEMBL8623907 | 0.93 | PRKCI (0.46) | PRKCIPRKCZKDM4EHSD17B10TP53 | |
| SCHEMBL8626015 | 0.92 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL8622871 | 0.90 | EDNRA (0.51) | PRKCIPRKCZEDNRASCN9ACYP19A1 | |
| SCHEMBL8620432 | 0.88 | EDNRA (0.51) | PRKCIPRKCZKDM4EHSD17B10TP53 | |
| SCHEMBL7534451 | 0.84 | EDNRA (0.48) | EDNRASCN9AEDNRB | |
| SCHEMBL7538989 | 0.79 | SCN9A (0.47) | EDNRASCN9AEDNRB | |
| SCHEMBL7538071 | 0.78 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL7534309 | 0.77 | EDNRA (0.55) | EDNRASCN9AEDNRB | |
| SCHEMBL7538297 | 0.77 | SCN9A (0.46) | EDNRASCN9AEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271399-B1 | METHYL 3-(3,4-METHYLENEDIOXYPHENYL)-6-(PROP-1-YLOXY)-INDANE-2-CARBOXYLATE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-08-07 | — | — | US | disclosed |
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |