Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7943526 | 0.90 | MTOR (0.47) | MTORCYP3A4L3MBTL1RPTORMLST8 | |
| SCHEMBL10221554 | 0.82 | MTOR (0.71) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL7946985 | 0.78 | MTOR (0.62) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL2625409 | 0.73 | MTOR (0.71) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL9951464 | 0.73 | MTOR (0.71) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL15196056 | 0.71 | MTOR (0.74) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL7936477 | 0.71 | MTOR (0.64) | MTORCYP3A4 | |
| SCHEMBL15196054 | 0.71 | MTOR (0.60) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL1830223 | 0.68 | MTOR (0.69) | MTORCYP3A4RPTORMLST8MEN1 | |
| SCHEMBL1830231 | 0.68 | MTOR (0.69) | MTORCYP3A4RPTORMLST8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |