Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1833069 | 0.87 | MTOR (0.82) | MTORCYP3A4RPTORMLST8PIK3CA | |
| SCHEMBL1833066 | 0.87 | MTOR (0.82) | MTORCYP3A4RPTORMLST8PIK3CA | |
| SCHEMBL7943526 | 0.79 | MTOR (0.47) | MTORCYP3A4RPTORMLST8PIK3CA | |
| SCHEMBL1831558 | 0.78 | MTOR (0.85) | MTORCYP3A4RPTORMLST8PIK3CA | |
| SCHEMBL1831561 | 0.78 | MTOR (0.85) | MTORCYP3A4RPTORMLST8PIK3CA | |
| SCHEMBL7945524 | 0.78 | MTOR (0.47) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL2097407 | 0.78 | MTOR (0.75) | MTORCYP3A4RPTORMLST8PIK3CA | |
| SCHEMBL2625424 | 0.78 | MTOR (0.75) | MTORCYP3A4RPTORMLST8PIK3CA | |
| SCHEMBL7936477 | 0.77 | MTOR (0.64) | MTORCYP3A4 | |
| SCHEMBL1831968 | 0.77 | MTOR (1.00) | MTORCYP3A4RPTORMLST8PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |