Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.67 |
| ▸ | ITGAV | P06756 | 20/20 | 0.67 |
| ▸ | ITGB5 | P18084 | 8/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368823 | 1.00 | ITGB3 (0.67) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL7945682 | 0.85 | ITGB3 (0.65) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL7945684 | 0.85 | ITGB3 (0.65) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL6432333 | 0.81 | ITGAV (0.68) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL6432181 | 0.81 | ITGAV (0.68) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL6432177 | 0.81 | ITGAV (0.68) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL3889356 | 0.81 | ITGAV (0.72) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL3889354 | 0.81 | ITGAV (0.72) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL4368391 | 0.80 | ITGAV (0.74) | ITGB3ITGAVITGB5 | |
| SCHEMBL4371251 | 0.80 | ITGAV (0.74) | ITGB3ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268378-B1 | TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH. | MERCK & CO., INC. | 2001-07-31 | — | — | US | disclosed |
| US-6066648-A | USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH | MERCK & CO., INC. (US) | 2000-05-23 | — | — | US | disclosed |