Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.53 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.46 |
| ▸ | TUBB | P07437 | 2/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936838 | 0.88 | TUBB4A (0.57) | ESR1ESR2APPTUBB4ATUBB | |
| SCHEMBL7936824 | 0.83 | ESR1 (0.56) | ESR1SULT1A1ESR2APPTUBB4A | |
| SCHEMBL7945788 | 0.83 | ESR1 (0.53) | ESR1SULT1A1ESR2APPTUBB4A | |
| SCHEMBL14613446 | 0.81 | ESR1 (0.76) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7075381 | 0.80 | ESR1 (0.72) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL28515985 | 0.79 | TDP1 (0.59) | L3MBTL1TDP1CNR1CNR2 | |
| SCHEMBL7075664 | 0.79 | ESR1 (0.74) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7075631 | 0.79 | ESR1 (0.74) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL10170739 | 0.77 | HSP90AA1 (0.57) | ESR1ESR2APPTUBB4ATUBB | |
| SCHEMBL11550840 | 0.77 | CNR1 (0.71) | ESR1ESR2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | claimed |
| US-6087378-A | THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2000-07-11 | — | — | US | claimed |
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | disclosed |
| US-6087378-A | THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2000-07-11 | — | — | US | disclosed |