Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9246548 | 0.90 | POLB (0.60) | POLBKDM4EELANEMAPTALDH1A1 | |
| SCHEMBL6290006 | 0.85 | POLB (0.63) | POLBKDM4EELANEMAPTALDH1A1 | |
| SCHEMBL7945939 | 0.83 | KDM4E (0.46) | POLBKDM4EELANEMAPTALDH1A1 | |
| SCHEMBL28602356 | 0.81 | CYP3A4 (0.61) | POLBGAATNFSF11MAPK1BACE1 | |
| SCHEMBL28659652 | 0.81 | POLB (0.58) | POLBKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL28611062 | 0.80 | POLB (0.43) | POLBKDM4EMAPTTNFSF11MAPK1 | |
| SCHEMBL6292873 | 0.79 | POLB (0.53) | POLBMAPTTNFSF11TSHRKMT2A | |
| SCHEMBL6292857 | 0.79 | POLB (0.53) | POLBKDM4EELANEALDH1A1HSD17B10 | |
| SCHEMBL7003913 | 0.78 | POLB (0.56) | POLBKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL7952926 | 0.77 | KDM4E (0.70) | POLBKDM4EELANEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245779-B1 | ANALGESICS; ANTIINFLAMMATORY AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0997463-A1 | NAPHTHYRIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-05-03 | — | — | EP | disclosed |