Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945941 | 0.83 | POLB (0.58) | KDM4EELANEMAPTALDH1A1GLA | |
| SCHEMBL7954357 | 0.79 | LMNA (0.46) | KDM4EELANEMAPTGAAHSD17B10 | |
| SCHEMBL7952923 | 0.77 | KDM4E (0.68) | KDM4EELANEMAPTALDH1A1HSD17B10 | |
| SCHEMBL20099114 | 0.76 | KDM4E (0.53) | KDM4EELANEMAPTALDH1A1GLA | |
| SCHEMBL3292047 | 0.74 | KDM4E (0.53) | KDM4EELANEMAPTALDH1A1GLA | |
| SCHEMBL9246548 | 0.74 | POLB (0.60) | KDM4EELANEMAPTALDH1A1GLA | |
| SCHEMBL7956511 | 0.73 | CYP3A4 (0.55) | MAPTHSD17B10MAPK1LMNATP53 | |
| SCHEMBL2096627 | 0.73 | MAPT (0.45) | KDM4EELANEMAPTALDH1A1GLA | |
| SCHEMBL2096629 | 0.73 | MAPT (0.45) | KDM4EELANEMAPTALDH1A1GLA | |
| SCHEMBL2010436 | 0.72 | LMNA (0.59) | KDM4EELANEMAPTALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245779-B1 | ANALGESICS; ANTIINFLAMMATORY AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0997463-A1 | NAPHTHYRIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-05-03 | — | — | EP | disclosed |