Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 6/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.44 |
| ▸ | TPH1 | P17752 | 2/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861143 | 1.00 | ACACB (0.44) | ACACBCPB2NNMTTPH1KLKB1 | |
| SCHEMBL3861562 | 0.90 | MAPT (0.48) | ACACBCPB2TPH1FFAR1MAPT | |
| SCHEMBL7081683 | 0.89 | ACACB (0.49) | ACACBNNMTKLKB1MKNK1MKNK2 | |
| SCHEMBL3604889 | 0.89 | ACACB (0.49) | ACACBNNMTKLKB1MKNK1MKNK2 | |
| SCHEMBL6263178 | 0.84 | ACACB (0.45) | ACACBCPB2NNMTKLKB1MKNK1 | |
| SCHEMBL4601596 | 0.84 | HSD17B10 (0.53) | ACACBNNMTTPH1KLKB1FFAR1 | |
| SCHEMBL4601600 | 0.84 | HSD17B10 (0.53) | ACACBNNMTTPH1KLKB1FFAR1 | |
| SCHEMBL7018374 | 0.84 | ACACB (0.43) | ACACBNNMTKLKB1MKNK1MKNK2 | |
| SCHEMBL10741906 | 0.81 | ACACB (0.40) | ACACBCPB2NNMTKLKB1MKNK1 | |
| SCHEMBL7960935 | 0.80 | SLC7A5 (0.48) | CPB2TPH1PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268378-B1 | TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH. | MERCK & CO., INC. | 2001-07-31 | — | — | US | disclosed |