Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.61 |
| ▸ | EDNRB | P24530 | 5/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | DHPS | P49366 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946111 | 0.93 | EDNRA (0.73) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7589737 | 0.92 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL7583371 | 0.88 | EDNRA (0.58) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7586176 | 0.88 | EDNRA (0.68) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7596382 | 0.87 | EDNRA (0.65) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7591783 | 0.86 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL7586114 | 0.85 | EDNRA (0.75) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| Benzamide SCHEMBL7583369 | 0.83 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL7591775 | 0.83 | EDNRB (0.51) | EDNRAEDNRB | |
| SCHEMBL7596644 | 0.82 | EDNRA (0.57) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |