Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.60 |
| ▸ | EDNRB | P24530 | 8/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948180 | 0.93 | EDNRA (0.60) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7947634 | 0.92 | EDNRA (0.63) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL9156436 | 0.89 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL7946238 | 0.87 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL9156305 | 0.85 | EDNRA (0.56) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7332503 | 0.85 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL8325940 | 0.84 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8327615 | 0.83 | EDNRA (0.72) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7331071 | 0.83 | EDNRA (0.61) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7293947 | 0.83 | EDNRA (0.56) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-5420129-A | Treatment of hypertension, ischemia, vasospasms, angina | HOFFMANN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |