Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.56 |
| ▸ | EDNRB | P24530 | 5/20 | 0.44 |
| ▸ | CCR9 | P51686 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332503 | 0.92 | EDNRA (0.57) | EDNRAEDNRBCCR9 | |
| SCHEMBL7293947 | 0.88 | EDNRA (0.56) | EDNRAEDNRBCCR9 | |
| SCHEMBL8327615 | 0.87 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL7948180 | 0.84 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL7946205 | 0.84 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL8325396 | 0.84 | ALDH1A1 (0.46) | EDNRAEDNRB | |
| SCHEMBL7947634 | 0.83 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL9156436 | 0.82 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL7017153 | 0.81 | EDNRA (0.57) | EDNRAEDNRBCCR9 | |
| SCHEMBL9156305 | 0.80 | EDNRA (0.56) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |