Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10252171 | 0.90 | IKBKB (0.45) | NPC1RAB9AIKBKBHDAC2PDE4A | |
| SCHEMBL1274980 | 0.90 | DDB1 (0.44) | HDAC2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3237381 | 0.84 | DDB1 (0.43) | HDAC2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15874659 | 0.84 | DDB1 (0.43) | HDAC2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2199831 | 0.79 | SMN1; SMN2 (0.41) | NPC1RAB9AHDAC2PDE4APDE4B | |
| SCHEMBL9800296 | 0.79 | ESR2 (0.49) | HDAC2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21009133 | 0.79 | TP53 (0.46) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL22660215 | 0.79 | TDP1 (0.43) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8177567 | 0.78 | DDB1 (0.52) | IKBKBHDAC2PDE4APDE4BPDE4C | |
| SCHEMBL3584879 | 0.78 | DDB1 (0.52) | IKBKBHDAC2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038167-A1 | OXOPIPERIDINYL AND PYRANYL SULFONAMIDES AS AMPA POTENTIATORS | PFIZER INC. (US) | 2010-04-08 | — | — | WO | disclosed |