Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 11/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3497573 | 0.89 | ESR2 (0.56) | ESR2ESR1PDE4APDE4BPDE4C | |
| SCHEMBL14458014 | 0.84 | ESR2 (0.51) | ESR2ESR1PDE4APDE4BPDE4C | |
| SCHEMBL2199831 | 0.82 | SMN1; SMN2 (0.41) | ESR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21009133 | 0.82 | TP53 (0.46) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL22660215 | 0.82 | TDP1 (0.43) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL1274980 | 0.81 | DDB1 (0.44) | PDE4APDE4BPDE4CPDE4DHDAC2 | |
| SCHEMBL7946211 | 0.79 | NPC1 (0.39) | PDE4APDE4BPDE4CPDE4DHDAC2 | |
| SCHEMBL29743248 | 0.79 | ESR2 (0.44) | ESR2ESR1GUSBKMT2A | |
| SCHEMBL620339 | 0.79 | ESR2 (0.44) | ESR2ESR1GUSBKMT2A | |
| SCHEMBL8530446 | 0.78 | PARP1 (0.46) | ESR1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417143-A1 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| WO-1989011856-A2 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1989-12-14 | — | — | WO | disclosed |