Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.71 |
| ▸ | EDNRB | P24530 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946213 | 0.91 | EDNRA (0.71) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7948316 | 0.84 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL7849770 | 0.83 | EDNRA (1.00) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL6766267 | 0.81 | EDNRA (0.73) | EDNRAEDNRB | |
| SCHEMBL7939644 | 0.80 | EDNRA (0.67) | EDNRAEDNRB | |
| Bms-182874 SCHEMBL802730 | 0.79 | EDNRA (1.00) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| Bms-182874 SCHEMBL117150 | 0.78 | EDNRA (0.98) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7949150 | 0.78 | EDNRA (0.75) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL8784759 | 0.78 | EDNRA (0.65) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7947202 | 0.77 | EDNRA (0.74) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | disclosed |