Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785066 | 0.92 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL6771045 | 0.82 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL7951178 | 0.81 | P2RY1 (0.64) | — | |
| SCHEMBL7948316 | 0.81 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL7849770 | 0.81 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL6771238 | 0.81 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL8784309 | 0.81 | P2RY1 (0.63) | — | |
| SCHEMBL8785104 | 0.81 | EDNRA (1.00) | EDNRA | |
| SCHEMBL6770134 | 0.80 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL7946231 | 0.80 | EDNRA (0.71) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | disclosed |