Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777719 | 0.92 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL6767638 | 0.88 | EDNRB (0.74) | EDNRAEDNRB | |
| SCHEMBL6772509 | 0.86 | EDNRB (0.72) | EDNRAEDNRB | |
| SCHEMBL9088050 | 0.86 | EDNRA (0.77) | EDNRAEDNRB | |
| SCHEMBL6778007 | 0.85 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL6771743 | 0.82 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL6768276 | 0.80 | EDNRB (0.72) | EDNRAEDNRB | |
| SCHEMBL6773114 | 0.80 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL6771913 | 0.80 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL6767698 | 0.79 | EDNRA (1.00) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | claimed |
| EP-0569193-A1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-11-10 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| EP-0569193-A1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-11-10 | — | — | EP | disclosed |