SCHEMBL7946313

SCHEMBL7946313

O=C1CC(Cc2ccc(Cl)cc2)(NC(=O)N2C(=O)[C@@H](NC(=O)c3nccc4ccccc34)CN(C(=O)CO)c3ccccc32)C(=O)O1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 16/20 0.35
CASP8 Q14790 11/20 0.35
CASP3 P42574 2/20 0.32
XIAP P98170 2/20 0.32
DRD2 P14416 1/20 0.31
DRD1 P21728 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNA7 P36544 1/20 0.31
CHRNA4 P43681 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL646744 0.79 CASP1 (0.45) CASP1CASP8CASP3XIAP
SCHEMBL646053 0.77 CASP1 (0.38) CASP1CASP8CASP3XIAP
SCHEMBL646054 0.73 CASP1 (0.55) CASP1CASP8CASP3XIAP
SCHEMBL646090 0.71 CASP1 (0.47) CASP1CASP8CASP3
SCHEMBL647495 0.68 CASP1 (0.40) CASP1CASP8CASP3XIAP
SCHEMBL647496 0.66 CASP1 (0.53) CASP1CASP8CASP3XIAP
SCHEMBL10200558 0.66 CASP1 (0.47) CASP1CASP8CASP3XIAP
SCHEMBL13139800 0.66 CASP1 (0.47) CASP1CASP8CASP3XIAP
SCHEMBL644943 0.66 CASP1 (0.47) CASP1CASP8CASP3XIAP
SCHEMBL645928 0.65 CASP1 (0.55) CASP1CASP8CASP3XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258948-B1 AN N-ACYLAMINO COMPOUND; ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES VERTEX PHARMACEUTICALS, INCORPORATED 2001-07-10 US disclosed