Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
| ▸ | FEN1 | P39748 | 3/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | KAT7 | O95251 | 2/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.43 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946337 | 1.00 | SCN9A (0.52) | SCN9AFEN1ALOX5APCHEK2IDO1 | |
| SCHEMBL7946350 | 0.87 | FEN1 (0.55) | SCN9AFEN1ALOX5APCHEK2KAT7 | |
| SCHEMBL7946352 | 0.87 | FEN1 (0.55) | SCN9AFEN1ALOX5APCHEK2KAT7 | |
| SCHEMBL29576187 | 0.81 | CHEK2 (0.51) | SCN9AFEN1ALOX5APCHEK2FPR3 | |
| SCHEMBL15638179 | 0.81 | CHEK2 (0.51) | SCN9AFEN1ALOX5APCHEK2FPR3 | |
| SCHEMBL27158910 | 0.79 | SCN9A (0.55) | SCN9AFEN1ALOX5APCHEK2KAT7 | |
| SCHEMBL21604498 | 0.79 | CHEK2 (0.56) | SCN9AFEN1ALOX5APCHEK2BACE1 | |
| SCHEMBL21604654 | 0.79 | CHEK2 (0.56) | SCN9AFEN1ALOX5APCHEK2BACE1 | |
| SCHEMBL20281486 | 0.79 | CHEK2 (0.56) | SCN9AFEN1ALOX5APCHEK2BACE1 | |
| SCHEMBL16688859 | 0.78 | CYP2C9 (0.47) | SCN9AFEN1ALOX5APCHEK2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262078-B1 | Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain | SYNTEX (U.S.A.) LLC | 2001-07-17 | — | — | US | disclosed |
| US-6110937-A | A SODIUM CHANNEL BLOCKER TREATING AS LOCAL ANESTHETICS AND IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | SYNTEX USA, INC. (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0869119-A1 | Phenoxymethyl piperidine derivatives being sodium channle blockers | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-07 | — | — | EP | disclosed |
| CN-1194977-A | Phenoxymethyl piperidine derivatives | HOFFMANN LA ROCHE (CH) | 1998-10-07 | — | — | CN | disclosed |