Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 4/20 | 0.55 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.55 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | KAT7 | O95251 | 1/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946350 | 1.00 | FEN1 (0.55) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL27158910 | 0.88 | SCN9A (0.55) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL7946337 | 0.87 | SCN9A (0.52) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL7946335 | 0.87 | SCN9A (0.52) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL3323433 | 0.84 | FEN1 (0.56) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL3323442 | 0.84 | FEN1 (0.56) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL3443787 | 0.84 | CHEK2 (0.56) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL3443784 | 0.84 | CHEK2 (0.56) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL3326965 | 0.83 | ALOX5AP (0.57) | FEN1ALOX5APACKR3SCN9ACHEK2 | |
| SCHEMBL3326969 | 0.83 | ALOX5AP (0.57) | FEN1ALOX5APACKR3SCN9ACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262078-B1 | Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain | SYNTEX (U.S.A.) LLC | 2001-07-17 | — | — | US | disclosed |
| US-6110937-A | A SODIUM CHANNEL BLOCKER TREATING AS LOCAL ANESTHETICS AND IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | SYNTEX USA, INC. (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0869119-A1 | Phenoxymethyl piperidine derivatives being sodium channle blockers | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-07 | — | — | EP | disclosed |