Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.51 |
| ▸ | MTOR | P42345 | 11/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6898844 | 0.85 | MTOR (0.69) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL8050423 | 0.85 | PIK3CA (0.62) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL7953828 | 0.84 | PIK3CA (0.51) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL7953012 | 0.82 | PIK3CA (0.52) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL7955199 | 0.81 | FLT3 (0.53) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL7953276 | 0.81 | PIK3CA (0.52) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL1578267 | 0.80 | ADORA2A (0.47) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL7956679 | 0.79 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL7954509 | 0.79 | PIK3CA (0.50) | PIK3CAMTORPIK3R1PIK3CGPIK3CB | |
| SCHEMBL7955237 | 0.79 | PIK3CA (0.71) | PIK3CAMTORPIK3R1PIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD. (SG) | 2011-05-05 | — | — | US | disclosed |
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD. (SG) | 2011-05-05 | — | — | US | disclosed |
| WO-2009157880-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD (SG) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | MTOR, PIK3CA, TYMP | PIK3CA 2/4885MTOR 1/4885PIK3R1 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.