Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12303597 | 0.90 | BACE1 (0.54) | BACE1HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL7942878 | 0.87 | BACE1 (0.75) | BACE1BACE2 | |
| SCHEMBL7939911 | 0.85 | BACE1 (0.64) | BACE1BACE2 | |
| SCHEMBL7940775 | 0.85 | BACE1 (0.59) | BACE1HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL7933179 | 0.85 | BACE1 (0.76) | BACE1HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL7941880 | 0.85 | SMN1; SMN2 (0.57) | BACE1BACE2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7941874 | 0.84 | BACE1 (0.60) | BACE1BACE2AURKAAURKB | |
| SCHEMBL7944835 | 0.84 | BACE1 (0.54) | BACE1HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL7941875 | 0.83 | BACE1 (0.73) | BACE1BACE2 | |
| SCHEMBL7945376 | 0.83 | BACE1 (0.54) | BACE1BACE2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |