SCHEMBL7947276

SCHEMBL7947276

CCOC(=O)CC(C#N)(CC(=O)OCC)c1cccc(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
HPGD P15428 1/20 0.44
XPO1 O14980 1/20 0.43
THRB P10828 1/20 0.43
MAPT P10636 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
GAA P10253 2/20 0.42
ATM Q13315 2/20 0.42
CYP2C9 P11712 2/20 0.42
ELANE P08246 1/20 0.42
ALOX12 P18054 1/20 0.42
KMT2A Q03164 2/20 0.42
POLB P06746 1/20 0.42
MEN1 O00255 1/20 0.41
KDM4E B2RXH2 1/20 0.41
HTT P42858 1/20 0.41
MAOB P27338 1/20 0.41
GRIN1 Q05586 2/20 0.41
GRIN2B Q13224 2/20 0.41
KCNN4 O15554 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11819398 0.86 LMNA (0.41) ALDH1A1MAPTSMN1; SMN2GAAKMT2A
SCHEMBL7956668 0.86 NPSR1 (0.47) ALDH1A1MAPTSMN1; SMN2GAAKMT2A
SCHEMBL31634484 0.84 EGFR (0.38) ALDH1A1HPGDMAPTSMN1; SMN2GAA
SCHEMBL7495674 0.84 MAPT (0.41) ALDH1A1HPGDXPO1MAPTSMN1; SMN2
SCHEMBL11460906 0.84 GAA (0.47) ALDH1A1SMN1; SMN2GAAELANEKMT2A
SCHEMBL2636117 0.83 SMN1; SMN2 (0.46) ALDH1A1MAPTSMN1; SMN2KMT2APOLB
SCHEMBL11816273 0.83 SMN1; SMN2 (0.42) ALDH1A1THRBMAPTSMN1; SMN2GAA
SCHEMBL6997548 0.81 ESR1 (0.37) ALDH1A1SMN1; SMN2GAAATMCYP2C9
SCHEMBL6997987 0.80 MAPT (0.36) ALDH1A1HPGDMAPTCYP2C9KDM4E
SCHEMBL7958117 0.79 GAA (0.47) ALDH1A1HPGDMAPTSMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329392-B1 ANTIALLERGENS AVENTIS PHARMACEUTICALS, INC. 2001-12-11 US disclosed
EP-0777666-B1 SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES MERRELL PHARMA INC (US) 1999-03-03 EP disclosed
US-5861416-A TREATMENT OF ASTHMA OR COUGH MERRELL PHARMACEUTICALS INC. (US) 1999-01-19 US disclosed
US-5824690-A TREATING ASTHMA, COUGH HOECHST MARION ROUSSEL INC. (US) 1998-10-20 US disclosed
EP-0696280-B1 SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS MERRELL PHARMA INC (US) 1997-09-24 EP disclosed
US-5661160-A ADMINISTERING AN ANTITUSSIVE AGENT FOR TREATING COUGH; TACHYKININ ANTAGONISM, SUBSTANCE P AND NEUROKININ A ANTAGONISM MERRELL PHARMACEUTICALS INC. (US) 1997-08-26 US disclosed
US-5648366-A TACHYKININ ANTAGONISTS USEFUL IN TREATING ASTHMA MERRELL PHARMACEUTICALS INC. (US) 1997-07-15 US disclosed
EP-0777666-A1 NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES MERRELL PHARMACEUTICALS INC. (US) 1997-06-11 EP disclosed
US-5635510-A TACHYKININ (ESPECIALLY SUBSTANCE P AND NEUROKININ A) ANTAGONISTS; ANTIINFLAMMATORY AGENTS, ANALGESICS; NERVOUS SYSTEM DISORDERS; BRONCHODILATOR AGENTS MERRELL PHARMACEUTICALS INC. (US) 1997-06-03 US disclosed
WO-1996006094-A1 NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES MERRELL PHARMACEUTICALS INC. (US) 1996-02-29 WO disclosed
EP-0696280-A1 SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS MERRELL DOW PHARMA (US) 1996-02-14 EP disclosed
WO-1994026735-A1 SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES USEFUL AS TACHYKININ ANTAGONISTS MERRELL DOW PHARMACEUTICALS INC. (US) 1994-11-24 WO disclosed