Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.60 |
| ▸ | EDNRB | P24530 | 18/20 | 0.60 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313203 | 0.85 | EDNRA (0.63) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6313421 | 0.76 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL4631823 | 0.75 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6313378 | 0.73 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL8653448 | 0.73 | EDNRA (0.59) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL13665431 | 0.72 | NPC1 (0.60) | EDNRAEDNRB | |
| SCHEMBL7946892 | 0.71 | EDNRA (0.49) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6314152 | 0.71 | EDNRA (0.66) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL5211709 | 0.69 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7949184 | 0.69 | EDNRA (0.50) | EDNRAEDNRBABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |