Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 16/20 | 0.59 |
| ▸ | EDNRB | P24530 | 15/20 | 0.59 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313203 | 0.75 | EDNRA (0.63) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4631823 | 0.75 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7947366 | 0.73 | EDNRA (0.60) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL13665431 | 0.73 | NPC1 (0.60) | EDNRAEDNRBALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL5211709 | 0.72 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL471080 | 0.71 | MAPT (0.57) | EDNRAEDNRBALDH1A1KDM4ETSHR | |
| SCHEMBL4631821 | 0.71 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6313421 | 0.70 | EDNRA (0.66) | EDNRAEDNRBALDH1A1LMNAKDM4E | |
| SCHEMBL7946892 | 0.70 | EDNRA (0.49) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6151306 | 0.70 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946552-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998013366-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-04-02 | — | — | WO | disclosed |