Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.37 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | ALPI | P09923 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170670 | 0.89 | PDE4B (0.45) | PDE4BPRMT5WDR77PDE3AROCK1 | |
| SCHEMBL7946540 | 0.82 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL2170742 | 0.75 | PRMT5 (0.36) | PDE4BPRMT5WDR77PDE3A | |
| SCHEMBL2172480 | 0.74 | PDE4B (0.51) | PDE4BPDE3A | |
| SCHEMBL2173257 | 0.73 | PDE4B (0.40) | PDE4BPDE3A | |
| SCHEMBL2171767 | 0.73 | PARP10 (0.48) | PDE4BPDE3A | |
| SCHEMBL2217843 | 0.72 | PRMT5 (0.37) | PDE4BPRMT5WDR77 | |
| SCHEMBL2459931 | 0.70 | PDE4B (0.44) | PDE4BPDE3A | |
| SCHEMBL2171869 | 0.68 | PDE4B (0.52) | PDE4BPDE3A | |
| SCHEMBL2172562 | 0.68 | PDE4B (0.52) | PDE4BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035745-A1 | HETEROCYCLIC BIARYL DERIVATIVE, AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT | 杏林製薬株式会社 (JP) | 2010-04-01 | — | — | WO | disclosed |