Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770711 | 0.90 | EDNRA (0.73) | EDNRAEDNRB | |
| SCHEMBL6766562 | 0.87 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL6777867 | 0.84 | EDNRA (0.86) | EDNRAEDNRB | |
| SCHEMBL6151288 | 0.84 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL6767702 | 0.83 | EDNRB (0.73) | EDNRAEDNRB | |
| SCHEMBL6772268 | 0.82 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL7954867 | 0.82 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL7956742 | 0.81 | EDNRA (0.77) | EDNRAEDNRB | |
| SCHEMBL6771908 | 0.81 | EDNRB (0.72) | EDNRAEDNRB | |
| SCHEMBL7947185 | 0.81 | EDNRA (1.00) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768305-A1 | N-Isoxazolyl-biphenylsulfonamide derivatives, their preparation and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-16 | — | — | EP | claimed |
| US-6271248-B1 | USED IN TREATING HYPERTENSION, PULMONARY HYPERTENSION, RENAL/ GLOMERULAR/MESANGIAL CELL DISORDERS, ENDOTOXEMIA, ISCHEMIA, TUMOR GROWTH, ATHERSCLEROSIS, RESTENOSIS, SUBARACHNOID HEMORRHAGE, PROSTATIC HYPERTROPHY, CONGESTIVE HEART FAILURE | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6080774-A | Substituted biphenylsulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-27 | — | — | US | disclosed |
| EP-0768305-A1 | N-Isoxazolyl-biphenylsulfonamide derivatives, their preparation and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |