Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957220 | 1.00 | PDE5A (0.55) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7948060 | 1.00 | PDE5A (0.55) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7957252 | 0.90 | PDE5A (0.52) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7957254 | 0.90 | PDE5A (0.52) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7959058 | 0.87 | PDE5A (0.53) | PDE5APDE4BPDE4D | |
| SCHEMBL7959060 | 0.87 | PDE5A (0.53) | PDE5APDE4BPDE4D | |
| SCHEMBL7957095 | 0.86 | PDE4B (0.53) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7957085 | 0.86 | PDE4B (0.53) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7961874 | 0.85 | PDE5A (0.49) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7961881 | 0.85 | PDE5A (0.49) | PDE5APDE4BNR3C1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |