Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961881 | 1.00 | PDE5A (0.49) | PDE5APDE4BNR3C1PGRFLT3 | |
| SCHEMBL4341467 | 0.89 | PDE4B (0.59) | PDE5APDE4BPDE4D | |
| SCHEMBL7957252 | 0.85 | PDE5A (0.52) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7957254 | 0.85 | PDE5A (0.52) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7948060 | 0.85 | PDE5A (0.55) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7957220 | 0.85 | PDE5A (0.55) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7948055 | 0.85 | PDE5A (0.55) | PDE5APDE4BNR3C1PDE4D | |
| SCHEMBL7955464 | 0.84 | L3MBTL1 (0.49) | PDE5APDE4BPDE4D | |
| SCHEMBL7955469 | 0.84 | L3MBTL1 (0.49) | PDE5APDE4BPDE4D | |
| SCHEMBL4339964 | 0.83 | PDE4B (0.68) | PDE5APDE4BFLT3TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |