Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 2/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958296 | 0.93 | MCL1 (0.56) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7959220 | 0.85 | MCL1 (0.59) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7960467 | 0.84 | MCL1 (0.53) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7958447 | 0.83 | MCL1 (0.54) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7959506 | 0.80 | MCL1 (0.60) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7959081 | 0.80 | MCL1 (0.53) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7948724 | 0.80 | MCL1 (0.55) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7960155 | 0.79 | MCL1 (0.59) | MCL1PPARGPPARAHTR6KDM4E | |
| SCHEMBL7958387 | 0.79 | HTR2C (0.51) | MCL1HTR6KDM4EALDH1A1BAD | |
| SCHEMBL7962451 | 0.79 | HTR6 (0.47) | MCL1HTR6TDP1BADBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |