Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.34 |
| ▸ | APP | P05067 | 4/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949179 | 0.88 | BACE1 (0.34) | BACE1APPAKR1B10MAPTAKR1A1 | |
| SCHEMBL7955451 | 0.78 | AKR1B1 (0.44) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL2376286 | 0.77 | AKR1B1 (0.42) | BACE1APPAKR1B10MAPTAKR1A1 | |
| SCHEMBL7971681 | 0.76 | AKR1B1 (0.45) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7948007 | 0.76 | BACE1 (0.37) | BACE1AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7957156 | 0.75 | BACE1 (0.37) | BACE1AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7956723 | 0.75 | BACE1 (0.37) | BACE1AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7947812 | 0.74 | BACE1 (0.36) | BACE1AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7963121 | 0.70 | BACE1 (0.36) | BACE1AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7948410 | 0.69 | BACE1 (0.41) | BACE1APPAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |