Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.44 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971681 | 0.90 | AKR1B1 (0.45) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7963773 | 0.85 | AKR1B1 (0.44) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7957216 | 0.84 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7948846 | 0.84 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7959038 | 0.82 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL1982373 | 0.80 | AKR1B1 (0.46) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7948451 | 0.78 | BACE1 (0.34) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7958118 | 0.76 | AKR1B1 (0.39) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7968863 | 0.76 | AKR1B1 (0.45) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL2376286 | 0.75 | AKR1B1 (0.42) | AKR1B1AKR1B10AKR1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |