Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 19/20 | 0.57 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1953704 | 0.90 | ANO1 (0.59) | ANO1ANO2TP53SMN1; SMN2 | |
| SCHEMBL12271479 | 0.89 | ANO1 (0.56) | ANO1ANO2 | |
| SCHEMBL12831275 | 0.83 | CNR1 (0.43) | ANO1ANO2TP53 | |
| SCHEMBL1950364 | 0.81 | ANO1 (0.59) | ANO1ANO2 | |
| SCHEMBL1953935 | 0.80 | CASP3 (0.53) | ANO1ANO2TP53SMN1; SMN2 | |
| SCHEMBL2184231 | 0.80 | ANO1 (0.47) | ANO1ANO2TP53SMN1; SMN2 | |
| SCHEMBL3630778 | 0.79 | ANO1 (0.71) | ANO1ANO2 | |
| SCHEMBL12271083 | 0.78 | ANO1 (0.58) | ANO1ANO2 | |
| SCHEMBL1954102 | 0.78 | ANO1 (0.61) | ANO1ANO2TP53SMN1; SMN2 | |
| SCHEMBL12319381 | 0.78 | ANO1 (0.60) | ANO1ANO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130245025-A1 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-7906553-B2 | Substituted thiophene modulators of intracellular calcium | CALCIMEDICA, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100261725-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2010-10-14 | — | — | US | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261725-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ANO1 114/4885ANO2 98/4885TP53 2681/4885 |
| US-20130245025-A1 | Compounds that modulate intracellular calcium | ORAI1, SARAF, RYR2 | ANO1 114/4885ANO2 98/4885TP53 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.