Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | HRH1 | P35367 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14631841 | 0.88 | DRD2 (1.00) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL1567427 | 0.88 | DRD2 (1.00) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL13440473 | 0.85 | DRD2 (0.74) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL1568871 | 0.83 | DRD2 (0.74) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL5057655 | 0.81 | DRD2 (0.54) | DRD2CHRM1DRD3DRD4HDAC8 | |
| SCHEMBL2036762 | 0.79 | DRD2 (0.67) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL13284556 | 0.78 | DRD2 (0.80) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL2615344 | 0.78 | DRD2 (0.69) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL2615341 | 0.78 | DRD2 (0.69) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL8022151 | 0.77 | DRD2 (0.80) | DRD2CHRM1DRD3LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653257-B2 | Dibenzothiazepine derivatives and uses thereof—424 | ASTRAZENECA AB (SE) | 2014-02-18 | — | — | US | disclosed |
| EP-2307389-B1 | DIBENZOTHIAZEPINE DERIVATIVE AND USE THEREOF | ASTRAZENECA AB (SE) | 2013-01-23 | — | — | EP | disclosed |
| US-20120202991-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | ASTRAZENECA AB (SE) | 2012-08-09 | — | — | US | disclosed |
| US-20110160184-A1 | Dibenzothiazepine Derivatives and Use Thereof | ASTRAZENECA AB (SE) | 2011-06-30 | — | — | US | disclosed |
| WO-2009154563-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USE THEREOF | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160184-A1 | Dibenzothiazepine Derivatives and Use Thereof | DRD2, DRD4, GABBR1 | DRD2 1/4885CHRM1 1350/4885DRD3 8/4885 |
| US-20120202991-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | DRD4, DRD2, GABBR1 | DRD2 2/4885CHRM1 1781/4885DRD3 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.