Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | POR | P16435 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069010 | 0.84 | TAAR1 (0.41) | MAPTRXFP1TAAR1CYP1A2CYP2A6 | |
| SCHEMBL16955527 | 0.83 | MAPT (0.39) | MAPTRXFP1TAAR1CYP1A2CYP2A6 | |
| SCHEMBL598593 | 0.81 | TAAR1 (0.44) | MAPTRXFP1TAAR1CYP1A2CYP2A6 | |
| Methane SCHEMBL27570896 | 0.79 | TAAR1 (0.43) | MAPTRXFP1TAAR1CYP1A2CYP2A6 | |
| SCHEMBL269825 | 0.77 | TAAR1 (0.58) | MAPTRXFP1TAAR1CYP1A2CYP2A6 | |
| SCHEMBL29462885 | 0.77 | TAAR1 (0.58) | MAPTRXFP1TAAR1CYP1A2CYP2A6 | |
| SCHEMBL4826085 | 0.77 | GRIN2D (0.36) | MAPTKDM4E | |
| SCHEMBL11252558 | 0.75 | TAAR1 (0.40) | MAPTRXFP1TAAR1CYP1A2CYP2A6 | |
| SCHEMBL720756 | 0.75 | TRPA1 (0.44) | MAPTTAAR1CYP1A2CYP2A6L3MBTL1 | |
| SCHEMBL9243180 | 0.74 | KMT2A (0.34) | MAPTRXFP1AMY1ASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291472-B1 | 4a, 5a, 8a, 8b-tetrahydro-6H-pyrrolo[3′,4′:4, 5]furo[3,2-b] pyri-dine-6,8(7H)-dione derivatives for control of endoparasites processes for their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-18 | — | — | US | disclosed |
| US-4338457-A | Composition and process | THE UPJOHN COMPANY (US) | 1982-07-06 | — | — | US | disclosed |
| US-4324889-A | 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6β-5-iodo-PGF1 amides | THE UPJOHN COMPANY (US) | 1982-04-13 | — | — | US | disclosed |
| US-4289893-A | 2,5-Inter-O-phenylene-3,4-dinor-PGF2 compounds | THE UPJOHN COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
| US-4281113-A | 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6.beta.-5-iodo-PGF1 compounds | THE UPJOHN COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| US-4243592-A | THROMBOXANES; PROSTAGLANDINS; ANTIINFLAMMATORY AND BRONCHODILATOR AGENTS; ANTICOAGULANTS | THE UPJOHN COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4220796-A | 9-Deoxy-9-methylene-5,6-didehydro-PGF1 compounds | THE UPJOHN COMPANY (US) | 1980-09-02 | — | — | US | disclosed |
| US-4218378-A | 11a-Methano-TXA compounds | THE UPJOHN COMPANY (US) | 1980-08-19 | — | — | US | disclosed |