Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 18/20 | 0.75 |
| ▸ | TPSD1 | Q9BZJ3 | 18/20 | 0.75 |
| ▸ | TPSG1 | Q9NRR2 | 18/20 | 0.75 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.53 |
| ▸ | F2 | P00734 | 3/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420561 | 0.86 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL21813576 | 0.78 | TPSAB1 (0.44) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL31512307 | 0.77 | EPHX1 (0.61) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL30845393 | 0.76 | KDM4E (0.56) | TPSAB1TPSD1TPSG1 | |
| SCHEMBL7420226 | 0.76 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7467751 | 0.74 | TPSAB1 (0.62) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7962399 | 0.72 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7481954 | 0.72 | TPSAB1 (0.80) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7419760 | 0.71 | TPSAB1 (0.59) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7421217 | 0.70 | TPSAB1 (0.44) | TPSAB1TPSD1TPSG1PRSS1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |