Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 8/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3132226 | 0.91 | PDE4B (0.43) | PDE4BLMNAPOLBMAPTKMT2A | |
| SCHEMBL1157700 | 0.89 | PDE4B (0.44) | PDE4BGRM2NR3C2PDE4APDE4C | |
| SCHEMBL1159028 | 0.85 | GRM2 (0.44) | PDE4BLMNAPOLBMAPTKMT2A | |
| SCHEMBL3118133 | 0.85 | NAPRT (0.45) | PDE4BLMNAPOLBMAPTKMT2A | |
| SCHEMBL3132289 | 0.85 | PDE4B (0.43) | PDE4BGRM2NR3C2PRKDCPDE4A | |
| SCHEMBL3120667 | 0.85 | PDE4A (0.49) | PDE4BGRM2PDK1PDE4APDE4C | |
| SCHEMBL3121005 | 0.85 | PDE4B (0.41) | PDE4BGRM2NR3C2PDE4APDE4C | |
| SCHEMBL3121362 | 0.85 | PDE4B (0.43) | PDE4BGRM2PDE4AKCNH2 | |
| SCHEMBL3132285 | 0.85 | GRM2 (0.43) | PDE4BLMNAPOLBMAPTKMT2A | |
| SCHEMBL7945403 | 0.84 | PDE4B (0.43) | PDE4BLMNAPOLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |