Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.45 |
| ▸ | EDNRB | P24530 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949358 | 0.87 | EDNRA (0.59) | EDNRAEDNRBKDM4EMAPK1CASP1 | |
| SCHEMBL7047200 | 0.82 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL7046426 | 0.81 | MEN1 (0.61) | EDNRAKDM4EMAPK1CASP1MAPT | |
| SCHEMBL6313378 | 0.80 | EDNRA (0.63) | EDNRAEDNRBKDM4EMAPTNPC1 | |
| SCHEMBL7049154 | 0.78 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL7048685 | 0.77 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL7050601 | 0.76 | EDNRA (0.49) | EDNRAEDNRB | |
| SCHEMBL6313421 | 0.76 | EDNRA (0.66) | EDNRAEDNRBKDM4EMAPTNPC1 | |
| SCHEMBL27496308 | 0.76 | TAS1R3 (0.47) | EDNRAEDNRBKDM4EMAPTALDH1A1 | |
| SCHEMBL7045943 | 0.76 | EDNRA (0.48) | EDNRAEDNRBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |