Sugi Predict

Sugi Predict / Compounds / SCHEMBL7951501

SCHEMBL7951501

SCHEMBL7951501

O=C(Cl)c1cc2sccc2s1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR35 Q9HC97 3/20 0.69
▸ HDAC3 O15379 4/20 0.65
▸ HDAC4 P56524 4/20 0.65
▸ HDAC1 Q13547 4/20 0.65
▸ HDAC7 Q8WUI4 4/20 0.65
▸ HDAC2 Q92769 4/20 0.65
▸ HDAC10 Q969S8 4/20 0.65
▸ HDAC11 Q96DB2 4/20 0.65
▸ HDAC8 Q9BY41 4/20 0.65
▸ HDAC6 Q9UBN7 4/20 0.65
▸ HDAC9 Q9UKV0 4/20 0.65
▸ HDAC5 Q9UQL6 4/20 0.65
▸ GAA P10253 3/20 0.61
▸ ALDH1A1 P00352 3/20 0.61
▸ POLB P06746 1/20 0.56
▸ GLA P06280 1/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ TLK2 Q86UE8 2/20 0.41
▸ DAO P14920 1/20 0.35
▸ MEN1 O00255 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14854087 0.85 GPR35 (0.65) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL335232 0.82 GPR35 (1.00) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL8346793 0.80 GPR35 (0.69) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL5039555 0.80 GPR35 (0.69) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL1990998 0.79 GPR35 (0.62) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL12074964 0.78 GPR35 (0.67) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL14854094 0.78 GPR35 (0.72) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL14854212 0.77 GPR35 (0.65) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL9432718 0.76 GPR35 (0.68) GPR35HDAC3HDAC4HDAC1HDAC7
SCHEMBL2275083 0.76 HDAC3 (0.74) GPR35HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023074408-A1 THIOPHENE COMPOUND, METHOD FOR SYNTHESIZING SAME, AND COMPOSITION CONTAINING SAID THIOPHENE COMPOUND 四国化成工業株式会社 2023-05-04 — — WO disclosed
US-11008343-B2 Heterocyclic compound and organic electronic device comprising same LG CHEM, LTD. 2021-05-18 — — US disclosed
US-20190284210-A1 HETEROCYCLIC COMPOUND AND ORGANIC ELECTRONIC DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2019-09-19 — — US disclosed
US-20140051711-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2014-02-20 — — US disclosed
US-20140051711-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2014-02-20 — — US disclosed
US-20130245025-A1 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2013-09-19 — — US disclosed
US-20130245025-A1 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2013-09-19 — — US disclosed
US-8394848-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2013-03-12 — — US disclosed
US-8394848-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2013-03-12 — — US disclosed
US-8383670-B2 Trisubstituted thiophenes that modulate intracellular calcium CALCIMEDICA, INC. (US) 2013-02-26 — — US disclosed
US-20110136816-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2011-06-09 — — US disclosed
US-20110136816-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2011-06-09 — — US disclosed
WO-2011034962-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2011-03-24 — — WO disclosed
US-20110065724-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2011-03-17 — — US disclosed
US-20110065724-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2011-03-17 — — US disclosed
US-7906553-B2 Substituted thiophene modulators of intracellular calcium CALCIMEDICA, INC. (US) 2011-03-15 — — US disclosed
US-7906553-B2 Substituted thiophene modulators of intracellular calcium CALCIMEDICA, INC. (US) 2011-03-15 — — US disclosed
US-20100261725-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2010-10-14 — — US disclosed
US-20100261725-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2010-10-14 — — US disclosed
WO-2010027875-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2010-03-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100261725-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 GPR35 957/4885HDAC3 1653/4885HDAC4 1630/4885
US-20140051711-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 GPR35 957/4885HDAC3 1653/4885HDAC4 1630/4885
US-20190284210-A1 HETEROCYCLIC COMPOUND AND ORGANIC ELECTRONIC DEVICE COMPRISING SAME CYP1A1, CYP1B1, ODC1 GPR35 2970/4885HDAC3 4302/4885HDAC4 3314/4885
US-20130245025-A1 Compounds that modulate intracellular calcium ORAI1, SARAF, RYR2 GPR35 957/4885HDAC3 1653/4885HDAC4 1630/4885
US-20110136816-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 GPR35 957/4885HDAC3 1653/4885HDAC4 1630/4885
US-11008343-B2 Heterocyclic compound and organic electronic device comprising same CYP1A1, CYP1B1, ODC1 GPR35 2970/4885HDAC3 4302/4885HDAC4 3314/4885
US-20110065724-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 GPR35 957/4885HDAC3 1653/4885HDAC4 1630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.