Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 6/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12235650 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL13187308 | 0.83 | KDM4E (0.44) | ALDH1A1KDM4EHPGDHSD17B10APP | |
| SCHEMBL12258450 | 0.81 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL13105701 | 0.80 | APP (0.66) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL10779928 | 0.79 | KDM4E (0.46) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL13113628 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL14665012 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10RAB9AMEN1 | |
| SCHEMBL15046557 | 0.77 | CHRM2 (0.60) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL28415110 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL11935610 | 0.76 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294557-B1 | ANALGESIC AT CENTRAL NERVOUS SYSTEM IN THE MAMMALIAN SUBJECT. ALSO, THESE COMPOUNDS ARE INFLAMMATORY PAIN CAUSED, FOR EXAMPLE BY BURNS (INDUCED BY A CONTACT WITH HEAT, ACID OR THE OTHER RHEUMATISM OR THE LIKE, IN THE SAID SUBJECT. | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |