Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951875 | 1.00 | CYP19A1 (0.55) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL7953939 | 0.90 | MAPT (0.50) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL7953943 | 0.90 | MAPT (0.50) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL7779864 | 0.80 | HTR2A (0.44) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL7779856 | 0.80 | HTR2A (0.44) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL7779860 | 0.80 | HTR2A (0.44) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL4690945 | 0.79 | ALDH1A1 (0.40) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL7951341 | 0.79 | CYP19A1 (0.47) | CYP19A1CYP11B2ALDH1A1MAPTKDM4E | |
| SCHEMBL4685573 | 0.79 | ALDH1A1 (0.40) | CYP19A1CYP11B2ALDH1A1MAPTMAPK1 | |
| SCHEMBL1688133 | 0.79 | CYP19A1 (0.47) | CYP19A1CYP11B2ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235789-B1 | GLANDULAR DISORDERS; SLEEP DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0781271-A1 | BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008466-A1 | BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-21 | — | — | WO | disclosed |