SCHEMBL7952137

SCHEMBL7952137

Cc1cccc(-c2cccc(CCc3cccc(-c4cccc(C)n4)n3)n2)n1

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.70
CCR8 P51685 1/20 0.70
METAP2 P50579 1/20 0.48
NOS2 P35228 4/20 0.47
NOS1 P29475 3/20 0.47
CYP2A6 P11509 1/20 0.44
KCNH2 Q12809 2/20 0.43
NOS3 P29474 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
IRAK4 Q9NWZ3 3/20 0.41
HSD17B3 P37058 1/20 0.38
PDE10A Q9Y233 1/20 0.38
TGFBR1 P36897 1/20 0.38
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14732969 0.92 CCR1 (0.64) CCR1CCR8METAP2NOS2NOS1
SCHEMBL14224576 0.90 CCR1 (0.61) CCR1CCR8METAP2NOS2NOS1
SCHEMBL227749 0.87 CCR1 (0.57) CCR1CCR8METAP2NOS2NOS1
SCHEMBL24916774 0.86 CCR1 (0.52) CCR1CCR8NOS2NOS1KCNH2
SCHEMBL30201993 0.86 CCR1 (0.52) CCR1CCR8NOS2NOS1KCNH2
SCHEMBL14085152 0.85 CCR1 (0.67) CCR1CCR8METAP2NOS2NOS1
SCHEMBL10144469 0.84 KCNH2 (0.54) CCR1CCR8NOS2NOS1KCNH2
SCHEMBL10894853 0.83 CCR1 (0.64) CCR1CCR8METAP2NOS2NOS1
SCHEMBL196966 0.83 CCR1 (1.00) CCR1CCR8METAP2NOS2CYP2A6
SCHEMBL8908397 0.83 CCR1 (0.64) CCR1CCR8METAP2NOS2NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187928-B1 TREATING FUNGAL DISEASES THE ROCKEFELLER UNIVERSITY 2001-02-13 US disclosed
US-6087510-A Method of use of imidazolium cations THE ROCKEFELLER UNIVERSITY (US) 2000-07-11 US disclosed
US-5969150-A FLUORESCENT COMPOUNDS FOR MEDICAL DIAGNOSIS, DRUGS AND LABELS OR FUNGICIDES AND VIRICIDES THE ROCKEFELLER UNIVERSITY (US) 1999-10-19 US disclosed
US-5874587-A FLUORESCENCE THE ROCKEFELLER UNIVERSITY (US) 1999-02-23 US disclosed